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Mol Cell. 2016 Dec 15;64(6):1020-1021. doi: 10.1016/j.molcel.2016.11.038.

Back to the Roots: Deep View into the Evolutionary History of ADP-Ribosylation Opened by the DNA-Targeting Toxin-Antitoxin Module DarTG.

Author information

1
Center of Excellence for Bacterial Stress Response and Persistence, Department of Biology, University of Copenhagen, 2200 Copenhagen N, Denmark.
2
Center of Excellence for Bacterial Stress Response and Persistence, Department of Biology, University of Copenhagen, 2200 Copenhagen N, Denmark. Electronic address: kgerdes@bio.ku.dk.

Abstract

In this issue of Molecular Cell, Jankevicius et al. (2016) characterize the DarTG toxin-antitoxin module in which the DarT toxin ADP-ribosylates single-stranded DNA and the DarG antitoxin counteracts DarT by direct binding and by enzymatic removal of the ADP-ribosylation.

KEYWORDS:

ADP-ribosylation; DarG; DarT; bacterial persistence; restriction-modification system; toxin-antitoxin module

PMID:
27984742
DOI:
10.1016/j.molcel.2016.11.038
[Indexed for MEDLINE]
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