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Cell. 2016 Dec 15;167(7):1898-1898.e1. doi: 10.1016/j.cell.2016.11.043.

SnapShot: Cartography of Intramembrane Proteolysis.

Author information

1
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Room 507 PCTB, 725 North Wolfe Street, Baltimore, MD 21205, USA.

Abstract

Intramembrane proteases hydrolyze peptide bonds within the cell membrane as the decision-making step of various signaling pathways or during general proteostasis. Although initially thought to be rare, fourteen proteases from four superfamilies are now known to be distributed among nearly every membrane compartment of a human cell. Each protease is endowed with specific enzymatic properties that determine both substrate choice and outcome.

PMID:
27984738
DOI:
10.1016/j.cell.2016.11.043
[Indexed for MEDLINE]
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