Format

Send to

Choose Destination
Cell. 2016 Dec 15;167(7):1676-1678. doi: 10.1016/j.cell.2016.11.049.

A Zygotic Checkpoint for Unrepaired Lesions.

Author information

1
MGH Cancer Center and Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. Electronic address: zou.lee@mgh.harvard.edu.

Abstract

DNA demethylation, a process involving DNA repair, is critical for reprogramming of the paternal genome during the oocyte-to-zygote transition. A new study by Ladstätter and Tachibana-Konwalski shows that a Chk1-mediated zygotic checkpoint monitors the cohesin-dependent repair of DNA lesions arising from DNA demethylation, which prevents zygotes carrying unrepaired lesions from entering mitosis.

PMID:
27984718
DOI:
10.1016/j.cell.2016.11.049
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center