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Emerg Infect Dis. 2017 Jan;23(1):56-65. doi: 10.3201/eid2301.160608.

Analysis of Anthrax Immune Globulin Intravenous with Antimicrobial Treatment in Injection Drug Users, Scotland, 2009-2010.

Abstract

We studied anthrax immune globulin intravenous (AIG-IV) use from a 2009-2010 outbreak of Bacillus anthracis soft tissue infection in injection drug users in Scotland, UK, and we compared findings from 15 AIG-IV recipients with findings from 28 nonrecipients. Death rates did not differ significantly between recipients and nonrecipients (33% vs. 21%). However, whereas only 8 (27%) of 30 patients at low risk for death (admission sequential organ failure assessment score of 0-5) received AIG-IV, 7 (54%) of the 13 patients at high risk for death (sequential organ failure assessment score of 6-11) received treatment. AIG-IV recipients had surgery more often and, among survivors, had longer hospital stays than did nonrecipients. AIG-IV recipients were sicker than nonrecipients. This difference and the small number of higher risk patients confound assessment of AIG-IV effectiveness in this outbreak.

KEYWORDS:

AIG-IV; Bacillus anthracis; Scotland; United Kingdom; anthrax; anthrax immune globulin intravenous; bacteria; infection; injection drug users; treatment

PMID:
27983504
PMCID:
PMC5176236
DOI:
10.3201/eid2301.160608
[Indexed for MEDLINE]
Free PMC Article

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