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Arch Environ Occup Health. 2017 Nov 2;72(6):351-358. doi: 10.1080/19338244.2016.1272539. Epub 2016 Dec 16.

Urinary trans-trans muconic acid (exposure biomarker to benzene) and hippuric acid (exposure biomarker to toluene) concentrations in Mexican women living in high-risk scenarios of air pollution.

Author information

1
a Laboratorio de Toxicología Molecular, Centro de Investigación Aplicada en Ambiente y Salud (CIAAS), Coordinación para la Innovación y Aplicación de la Ciencia y la Tecnología (CIACYT), Universidad Autónoma de San Luis Potosí , San Luis Potosí , México.
2
b Facultad de Medicina, Universidad Autónoma de San Luis Potosí , San Luis Potosí , México.
3
c Unidad Académica Multidisciplinaria Zona Media, Universidad Autónoma de San Luis Potosí , Rio Verde, San Luis Potosí , México.

Abstract

This study aimed to determine t,t-muconic acid (t,t-MA; exposure biomarker for benzene) and hippuric acid (HA; exposure biomarker for toluene) concentrations in the urine of women living in Mexico. In a cross-sectional study, apparently healthy women (n = 104) were voluntarily recruited from localities with a high risk of air pollution; t,t-MA and HA in urine were quantified using a high-performance liquid chromatography (HPLC) technique. Mean urinary levels of t,t-MA ranged from 680 to 1,310 μg/g creatinine. Mean values of HA ranged from 0.38 to 0.87 g/g creatinine. In conclusion, compared to data recently reported in literature, we found high urinary levels of t,t-MA and HA in assessed women participating in this study. We therefore deem the implementation of a strategy aimed at the reduction of exposure as a necessary measure for the evaluated communities.

KEYWORDS:

Benzene; VOCs; hippuric acid; toluene; trans-trans muconic acid

PMID:
27982738
DOI:
10.1080/19338244.2016.1272539
[Indexed for MEDLINE]

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