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Int J Reprod Biomed (Yazd). 2016 Nov;14(11):687-690.

Efficacy of Intrauterine infusion of granulocyte colony stimulating factor on patients with history of implantation failure: A randomized control trial.

Author information

1
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
2
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.; Department of Obstetrics and Gynecology, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.
3
Department of Obstetrics and Gynecology, Endocrinology and Female Infertility Unit, Roointan Arash Women's Health Research and Educational Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Abstract

BACKGROUND:

Although pregnancy rate in in vitro fertilization-embryo transfer (IVF-ET) cycles has been increased over the preceding years, but the majority of IVF-ET cycles still fail. Granulocyte colony stimulating factor (GCSF) is a glycoprotein that stimulates cytokine growth factor and induces immune system which may improve pregnancy rate in women with history of implantation failure.

OBJECTIVE:

The aim of this study was to evaluate GCSF ability to improve pregnancy rate in women with history of implantation failure.

MATERIALS AND METHODS:

0.5 ml (300 µg/ml) GCSF was infused intrauterine in intervention group. Pregnancy outcomes were assessed based on clinical pregnancy.

RESULTS:

The mean age of participants was 31.95±4.71 years old. There were no significant differences between demographic characteristics in two groups (p>0.05). The pregnancy outcome in GCSF group was improved significantly (p=0.043).

CONCLUSION:

GCSF can improve pregnancy outcome in patients with history of implantation failure.

KEYWORDS:

GCSF; In vitro fertilization; Pregnancy rate

PMID:
27981253
PMCID:
PMC5153573

Conflict of interest statement

The authors declare that there was no conflict of interests regarding the publication of this article.

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