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Eur J Microbiol Immunol (Bp). 2016 Nov 3;6(4):298-305. eCollection 2016 Dec 1.

Influence of Toxoplasma Gondii Infection on Symptoms and Signs of Premenstrual Syndrome: A Cross-sectional Study.

Author information

1
Faculty of Medicine and Nutrition, Juárez University of Durango State , Avenida Universidad S/N, 34000 Durango, Dgo, Mexico.
2
Institute for Scientific Research "Dr. Roberto Rivera Damm", Juárez University of Durango State. Avenida Universidad S/N , 34000 Durango, Durango, Mexico.
3
Health Center No. 2 "Dr. Carlos Santamaría", Servicios de Salud de Durango , Durango, Mexico, Talpa S/N, 34170 Durango, Mexico.
4
Clínica de Medicina Familiar, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado , Predio Canoas S/N, 34079 Durango, Mexico.
5
Institute for Microbiology and Hygiene, Campus Benjamin Franklin, Charité Medical School , Hindenburgdamm 27, D-12203 Berlin, Germany.

Abstract

Infection with Toxoplasma gondii in brain may cause some symptoms that resemble those in women with premenstrual syndrome. To determine the association of T. gondii infection with symptoms and signs of premenstrual syndrome, we examined 489 women aged 30-40 years old. Sera of participants were analyzed for the presence of anti-Toxoplasma IgG and IgM antibodies using enzyme-linked immunoassays (EIA) and T. gondii DNA by polymerase chain reaction (PCR). Anti-T. gondii IgG antibodies were found in 38 (7.8%) of the women studied. Anti-T. gondii IgM antibodies were found in 13 (34.2%) of the 38 IgG seropositive women. Logistic regression showed two variables associated with seropositivity to T. gondii: presence of diarrhea (odds ratio [OR] = 6.10; 95% confidence interval [CI]: 1.37-27.85; P = 0.01) and weight gain (OR = 2.89; 95% CI: 1.37-6.07; P = 0.005), and two variables associated with high (>150 IU/ml) levels of IgG against T. gondii: presence of diarrhea (OR = 7.40; 95% CI: 1.79-30.46; P = 0.006) and abdominal inflammation (OR = 3.38; 95% CI: 1.13-10.10; P = 0.02). Positivity to EIA IgG and PCR was positively associated with obesity and negatively associated with joint pain by bivariate analysis. Our study for the first time reveals a potential association of T. gondii infection with clinical manifestations of premenstrual syndrome.

KEYWORDS:

Toxoplasma gondii; cross-sectional study; premenstrual syndrome; seroprevalence

Conflict of interest statement

The authors declare that no competing interests exist.

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