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Am J Surg. 2017 Oct;214(4):733-737. doi: 10.1016/j.amjsurg.2016.10.026. Epub 2016 Dec 1.

Risk of post-procedural bleeding in children on intravenous fish oil.

Author information

1
Vascular Biology Program and the Department of Surgery, Boston Children's Hospital, Boston, MA, USA.
2
Clinical Research Center, Biostatistics Core, Boston Children's Hospital, Boston, MA, USA.
3
Department of Pharmacy, Boston Children's Hospital, Boston, MA, USA.
4
Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.
5
Vascular Biology Program and the Department of Surgery, Boston Children's Hospital, Boston, MA, USA. Electronic address: mark.puder@childrens.harvard.edu.

Abstract

BACKGROUND:

Intestinal failure-associated liver disease (IFALD) can be treated with parenteral fish oil (FO) monotherapy, but practitioners have raised concerns about a potential bleeding risk. This study aims to describe the incidence of clinically significant post-procedural bleeding (CSPPB) in children receiving FO monotherapy.

METHODS:

A retrospective chart review was performed on patients at our institution treated with intravenous FO for IFALD. CSPPB was defined as bleeding leading to re-operation, transfer to the intensive care unit, re-admission, or death, up to one month after any invasive procedure.

RESULTS:

From 244 patients reviewed, 183 underwent ≥1 invasive procedure(s) (n = 732). Five (0.68%, 95% CI 0.22-1.59%) procedures resulted in CSPPB. FO therapy was never interrupted. No deaths due to bleeding occurred.

CONCLUSIONS:

Findings suggest that FO therapy is safe, with a CSPPB risk no greater than that reported in the general population. O3FA should not be held in preparation for procedures or in the event of bleeding.

KEYWORDS:

Fish oil; Intestinal failure-associated liver disease; Omega-3 fatty acids; Post-procedure bleeding

PMID:
27979360
PMCID:
PMC5464992
DOI:
10.1016/j.amjsurg.2016.10.026
[Indexed for MEDLINE]
Free PMC Article

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