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Methods Mol Biol. 2017;1549:101-107.

Proteotypic Peptides and Their Applications.

Author information

1
Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, 3086, Australia. S.Keerthikumar@latrobe.edu.au.
2
Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, 3086, Australia.

Abstract

Recent advances in mass spectrometry based proteomic techniques and publicly available large proteomic repositories are being exploited to characterize the proteome of multiple organisms. While humongous amount of proteomic data is being acquired and analyzed, many biological questions still remain unanswered. Proteotypic peptides which uniquely represent target proteins or a protein isoform are used as an alternative strategy for protein identification in the field of immunological methods and targeted proteomic techniques. Using different computational approaches, resources and techniques used in the identification of proteotypic peptides of target proteins is discussed here.

KEYWORDS:

Bioinformatics; Biomarkers; Databases; Selected reaction monitoring; Targeted proteomics

PMID:
27975286
DOI:
10.1007/978-1-4939-6740-7_8
[Indexed for MEDLINE]

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