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Eur Radiol. 2017 Aug;27(8):3156-3166. doi: 10.1007/s00330-016-4692-9. Epub 2016 Dec 14.

Dynamic contrast-enhanced MR imaging in predicting progression of enhancing lesions persisting after standard treatment in glioblastoma patients: a prospective study.

Author information

1
Department of Radiology, Seoul National University College of Medicine, 28, Yongon-dong, Chongno-gu, 110-744, Seoul, Korea.
2
Department of Radiology, Seoul National University College of Medicine, 28, Yongon-dong, Chongno-gu, 110-744, Seoul, Korea. verocay@snuh.org.
3
Center for Nanoparticle Research, Institute for Basic Science, and School of Chemical and Biological Engineering, Seoul National University, 151-742, Seoul, Korea. verocay@snuh.org.
4
School of Chemical and Biological Engineering, Seoul National University, Seoul, Korea. verocay@snuh.org.
5
Department of Internal Medicine, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.
6
Department of Neurosurgery, Biomedical Research Institute, Seoul National University College of Medicine, Seoul, Korea.
7
Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.
8
Department of Radiation Oncology, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.
9
Department of Neurology, Seoul National University College of Medicine, Seoul, Korea.

Abstract

OBJECTIVES:

To prospectively explore the value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in predicting the progression of enhancing lesions persisting after standard treatment in patients with surgically resected glioblastoma (GBM).

METHODS:

Forty-seven GBM patients, who underwent near-total tumorectomy followed by concurrent chemoradiation therapy (CCRT) with temozolomide (TMZ) between May 2014 and February 2016, were enrolled. Twenty-four patients were finally analyzed for measurable enhancing lesions persisting after standard treatment. DCE-MRI parameters were calculated at enhancing lesions. Mann-Whitney U tests and multivariable stepwise logistic regression were used to compare parameters between progression (n = 16) and non-progression (n = 8) groups.

RESULTS:

Mean Ktrans and ve were significantly lower in progression than in non-progression (P = 0.037 and P = 0.037, respectively). The 5th percentile of the cumulative Ktrans histogram was also significantly lower in the progression than in non-progression group (P = 0.017). Mean ve was the only independent predictor of progression (P = 0.007), with a sensitivity of 100%, specificity of 63%, and an overall accuracy of 88% at a cut-off value of 0.873.

CONCLUSIONS:

DCE-MRI may help predict the progression of enhancing lesions persisting after the completion of standard treatment in patients with surgically resected GBM, with mean ve serving as an independent predictor of progression.

KEY POINTS:

• Enhancing lesions may persist after standard treatment in GBM patients. • DCE-MRI may help predict the progression of the enhancing lesions. • Mean K trans and v e were lower in progression than in non-progression group. • DCE-MRI may help identify patients requiring close follow-up after standard treatment. • DCE-MRI may help plan treatment strategies for GBM patients.

KEYWORDS:

Chemoradiotherapy; Glioblastoma; Magnetic resonance imaging; Perfusion; Progression

PMID:
27975145
DOI:
10.1007/s00330-016-4692-9
[Indexed for MEDLINE]

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