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J Med Life. 2016 Jan-Mar;9(1):12-18.

Cushing's disease: a multidisciplinary overview of the clinical features, diagnosis, and treatment.

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Titu Maiorescu University, Faculty of Medicine, Bucharest, Romania; "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania; Bagdasar-Arseni Clinical Emergency Hospital, Bucharest, Romania.
"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania; C.I. Parhon National Institute of Endocrinology, Bucharest, Romania.


Cushing's disease is considered a rare condition characterized by the hypersecretion of the adrenocorticotropic hormone (ACTH) due to a pituitary adenoma that ultimately causes endogenous hypercortisolism by stimulating the adrenal glands. The clinical signs suggesting Cushing's disease, such as obesity, moon face, hirsutism, and facial plethora are already present on presentation. Endogenous hypercortisolism is associated with an increased risk of cardiovascular and metabolic manifestations, as well as respiratory disorders, psychiatric complications, osteoporosis and infections, leading to high rates of morbidity and mortality. It is vital to diagnose Cushing's disease as early as possible and to implement a treatment plan to lead to a successful prognosis and a low number of complications. The goal of this article was to review the clinical, diagnostic and treatment aspects of Cushing's disease using the most recent available guidelines.


ACTH hypersecretion; Cushing’s disease; adrenocorticotropic hormone; corticotrophin-releasing hormone; pituitary adenoma

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