Format

Send to

Choose Destination
Nat Rev Neurosci. 2016 Dec 15;18(1):20-30. doi: 10.1038/nrn.2016.162.

Structural plasticity and reorganisation in chronic pain.

Kuner R1,2, Flor H3,2.

Author information

1
Institute of Pharmacology, Heidelberg University.
2
Excellence Cluster 'Cellular Networks' Heidelberg University, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany.
3
Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, and Department of Psychology, University of Mannheim, J 5, 68159 Mannheim, Germany.

Abstract

Chronic pain is not simply a temporal continuum of acute pain. Studies on functional plasticity in neural circuits of pain have provided mechanistic insights and linked various modulatory factors to a change in perception and behaviour. However, plasticity also occurs in the context of structural remodelling and reorganisation of synapses, cells and circuits, potentially contributing to the long-term nature of chronic pain. This Review discusses maladaptive structural plasticity in neural circuits of pain, spanning multiple anatomical and spatial scales in animal models and human patients, and addresses key questions on structure-function relationships.

PMID:
27974843
DOI:
10.1038/nrn.2016.162
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center