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Phytochemistry. 2017 Mar;135:128-134. doi: 10.1016/j.phytochem.2016.12.006. Epub 2016 Dec 11.

Phenolic constituents from the root bark of Morus alba L. and their cardioprotective activity in vitro.

Author information

1
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, PR China.
2
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, PR China; School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, PR China.
3
School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, PR China.
4
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, PR China. Electronic address: fwsh@hactcm.edu.cn.

Abstract

A flavanone C-glycoside, steppogenin-5'-C-β-D-glucopyranoside, six prenylated 2-arylbenzofuran derivatives, moracin O-3″-O-β-D-glucopyranoside, moracin O-3'-O-β-D-xylopyranoside, moracin P-2″-O-β-D-glucopyranoside, moracin P-3'-O-β-D-glucopyranoside, moracin P-3'-O-α-L-arabinopyranoside and moracin P-3'-O-[β-D-glucopyranosyl-(1 → 2)]-α-L-arabinopyranoside, two phenolic acids, 2,4-dihydroxy-5-(4-hydroxybenzyl) benzoic acid and 2,4-dihydroxy-5-(3,4-dihydroxybenzyl) benzoic acid, as well as three known compounds, moracinoside C, moracin O, and moracin P were isolated from the root bark of Morus alba L. Their structures were ascertained on the basis of spectroscopic evidence. The protective effects of the compounds against doxorubicin-induced cardiomyopathy in H9c2 cells was investigated in vitro. Of all of the isolated compounds, moracin P-3'-O-β-D-glucopyranoside, moracin O and moracin P had a strong protective influence against doxorubicin-induced cell death with EC50 values of 9.5 ± 2.6, 4.5 ± 1.3, and 8.8 ± 2.4 μM, respectively.

KEYWORDS:

Cardioprotective effect; Moraceae; Morus alba L.; Phenolic constituents

PMID:
27974159
DOI:
10.1016/j.phytochem.2016.12.006
[Indexed for MEDLINE]

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