Format

Send to

Choose Destination
Mol Immunol. 2017 Jun;86:38-43. doi: 10.1016/j.molimm.2016.11.009. Epub 2016 Dec 11.

Salmonella-induced inflammasome activation in humans.

Author information

1
Institute for Molecular Bioscience, and Centre for Inflammation and Disease Research, The University of Queensland, St. Lucia, 4072, Australia.
2
Institute for Molecular Bioscience, and Centre for Inflammation and Disease Research, The University of Queensland, St. Lucia, 4072, Australia. Electronic address: K.Schroder@imb.uq.edu.au.

Abstract

Inflammasomes are macromolecular complexes that assemble upon recognition of pathogen- or danger-associated molecular patterns. Inflammasome assembly is nucleated by the oligomerisation of specific, activated pattern recognition receptors within the cytosol. Inflammasomes function as platforms for the activation of the caspase-1 protease, which in turn triggers the maturation and secretion of the pro-inflammatory cytokines IL-1β and IL-18, and initiates pyroptosis, a highly inflammatory form of lytic cell death. Recently, additional inflammatory caspases (murine caspase-11, and human caspase-4/5) were also reported to be activated upon a pyroptosis-inducing 'non-canonical inflammasome' by direct recognition of lipopolysaccharide (LPS), a pathogen-associated molecular pattern. Here we review and discuss recent advances in our understanding of inflammasome-mediated host defence against Salmonella particularly in human cells, and their implications for cellular survival and cytokine secretion.

KEYWORDS:

Caspase; Inflammasome; NOD-like receptor; Salmonella; Toll-like receptor

PMID:
27974148
DOI:
10.1016/j.molimm.2016.11.009
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center