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Int J Mol Sci. 2016 Dec 11;17(12). pii: E2082.

Pathophysiology of Non Alcoholic Fatty Liver Disease.

Author information

1
Gastroenterology, Di.Bi.M.I.S Policlinic Paolo Giaccone Hospital, University of Palermo, PC 90127, Palermo, Italy. petsa@inwind.it.
2
Cardiometabolic Risk Unit-Institute of Clinical Physiology, CNR, PC 56124, Pisa, Italy. amalia@ifc.cnr.it.
3
Department of Clinical and Experimental Medicine, University of Pisa, PC 56122, Pisa, Italy. elenirebelos@gmail.com.
4
Gastroenterology and Hepatology, Department of Medical Sciences, Città della, Salute e della Scienza di Torino Hospital, University of Turin, PC 10122, Turin, Italy. ebugianesi@yahoo.it.
5
Department of Nephrology, Urology and Renal Transplant-Fondazione IRCCS Ca', Granda, PC 20122 Milano, Italy. pmessa@policlinico.mi.it.
6
Institute of Internal Medicine, Gastroenterology and Liver Diseases Unit, Fondazione Policlinico Gemelli, Catholic University of Rome, PC 00168, Rome, Italy. luca.miele@policlinicogemelli.it.
7
Department of Gastroenterology 1 and Obesity 2, Polytechnic University of Marche, PC 60121, Ancona, Italy. gsvegliati@gmail.com.
8
Metabolic Liver Diseases-Università degli Studi Milano-Fondazione IRCCS Ca', Granda via F Sforza 35, PC 20122 Milano, Italy. luca.valenti@unimi.it.
9
Department of Clinical and Experimental Medicine, University of Pisa, PC 56122, Pisa, Italy. ferruccio.bonino@unipi.it.
10
Institute for Health, PC 53042, Chianciano Terme, Italy. ferruccio.bonino@unipi.it.

Abstract

The physiopathology of fatty liver and metabolic syndrome are influenced by diet, life style and inflammation, which have a major impact on the severity of the clinicopathologic outcome of non-alcoholic fatty liver disease. A short comprehensive review is provided on current knowledge of the pathophysiological interplay among major circulating effectors/mediators of fatty liver, such as circulating lipids, mediators released by adipose, muscle and liver tissues and pancreatic and gut hormones in relation to diet, exercise and inflammation.

KEYWORDS:

adiponectin; cholesterol; fatty liver; free fatty acids; ghrelin; glucagon; glucagon-like peptide 1; insulin; insulin resistance; irisin; leptin; selenoprotein P

PMID:
27973438
PMCID:
PMC5187882
DOI:
10.3390/ijms17122082
[Indexed for MEDLINE]
Free PMC Article

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