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Mutat Res. 1989 Oct;224(2):151-6.

The effect of smoking on the frequencies of asymmetrical and symmetrical chromosome exchanges in human lymphocytes.

Author information

1
Geoffrey Schofield Cytogenetics Laboratory, BNF plc, Sellafield, Cumbria, Great Britain.

Abstract

Cytogenetic analysis was performed on blood lymphocyte cultures from 12 moderate smokers (15-20 cigarettes/day) and 12 non-smokers. An increase in dicentrics was observed in the smokers using block-stained material but this was not significant. Analysis of banded material, enabling both symmetrical and asymmetrical aberrations to be scored, revealed a significant increase in total aberrations thus emphasizing the need to identify all chromosome rearrangements when examining the effects of low-level chronic exposures to clastogens.

PMID:
2797034
DOI:
10.1016/0165-1218(89)90150-x
[Indexed for MEDLINE]

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