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J Org Chem. 2017 Jan 6;82(1):664-672. doi: 10.1021/acs.joc.6b02672. Epub 2016 Dec 14.

Carboxylate-Enhanced Rhodium(III)-Catalyzed Aryl C-H Alkylation with Conjugated Alkenes under Mild Conditions.

Author information

1
School of Pharmaceutical Sciences, Jiangnan University , Lihu Road 1800, 214122 Wuxi, P.R. China.
2
Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen , Tammannstrasse 2, 37077 Göttingen, Germany.

Abstract

Rhodium(III)-catalyzed C-H bond functionalization for the synthesis of β-aryl aldehydes and ketones from (hetero)aryl oximes, pyri(mi)dine, as well as pyrazoles and α,β-unsaturated carbonyl compounds has been developed under exceedingly mild reaction conditions. Thus, the versatile rhodium(III) catalysis features high step- and atom-economy, oxidant-free reaction conditions, and broad substrate scope.

PMID:
27966963
DOI:
10.1021/acs.joc.6b02672

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