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Nat Prod Res. 2017 Aug;31(16):1869-1874. doi: 10.1080/14786419.2016.1263846. Epub 2016 Dec 14.

Potential hypoglycaemic activity phenolic glycosides from Moringa oleifera seeds.

Author information

1
a College of Pharmacy , Nanjing University of Chinese Medicine , Nanjing , P.R. China.
2
b Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization , Jiangsu , P.R. China.

Abstract

Moringa oleifera seed has remarkable curative effects on reducing blood pressure, blood sugar and enhancing human immunity. In this study, one novel phenolic glycoside (1) together with four known compounds 2-5 were isolated from the macroporous resin adsorption extract of M. oleifera seeds, and the compound 3 was reported for the first time from this plant. The structure of the new crystalline compound was determined on the basis of spectroscopic analyses including mass spectrometry, 1D and 2D NMR experiments. The hypoglycaemic activity of isolated compounds was investigated with HepG2 cell and STZ-induced mice. It was found that compound 1, 4 and 5 could promote the glucose consumption of insulin resistance cells and reduce blood glucose levels of STZ-induced mice. This study concludes that compound 1, 4 and 5 may be developed as new and safe hypoglycaemic drugs.

KEYWORDS:

HepG 2 cell; Moringa oleifera; hypoglycemic activity; phenolic glycoside

PMID:
27966373
DOI:
10.1080/14786419.2016.1263846
[Indexed for MEDLINE]

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