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Turk J Med Sci. 2016 Nov 17;46(5):1568-1572. doi: 10.3906/sag-1506-71.

Therapeutic effects of intralipid and medialipid emulsionsin a rat model of verapamil toxicity.

Author information

1
Department of Anesthesiology and Reanimation, Faculty of Medicine, Gazi University, Ankara, Turkey.
2
Laboratory Animal Breeding and Experimental Research Center, Faculty of Medicine, Gazi University, Ankara, Turkey.

Abstract

BACKGROUND/AIM:

Lipid emulsions are promising as a potential new therapy for severe verapamil overdose. Our purpose is to draw attention to the choice of solution by investigating the efficacy of intralipid 20% or medialipid 20% in verapamil overdose.

MATERIALS AND METHODS:

Eighteen adult Sprague Dawley rats were randomly divided into three groups: control (saline; Group C), intralipid 20% (Group I), and medialipid 20% (Group M). Rats were anesthetized with ketamine. Blood gas analysis, baseline heart rate (HRb), and mean arterial pressure (MAPb) were evaluated. Verapamil at 2.5 mg kg-1 min-1 was infused until the HRb and MAPb decreased by 50% and the times to HR0 and MAP0 were recorded. Treatment solutions of the groups were administered as 12.4 mL kg-1 in 5 min.

RESULTS:

While HR did not show a difference, MAP showed statistically significant differences among the groups. Intralipid 20% was more efficient than the other two treatments at an early stage; however, as the administration time progressed, medialipid 20% also turned out to be more efficient than the control treatment.

CONCLUSION:

Our findings indicate that in a toxicity model of rats produced with verapamil, intralipid 20% and medialipid 20% solutions partially eliminate cardiac-depressant effects and increase the survival rate.

KEYWORDS:

Verapamil; cardiovascular collapse; intralipid; medialipid; toxicity

PMID:
27966330
DOI:
10.3906/sag-1506-71
[Indexed for MEDLINE]

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