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Cancer Cell. 2016 Dec 12;30(6):836-848. doi: 10.1016/j.ccell.2016.10.009.

Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis.

Author information

1
Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, New York 10021, USA.
2
Pediatric Clinic III, University Clinic of Essen, Hufelandstrasse-55, Essen 45147, Germany.
3
Yonsei Cancer Center, Division of Medical Oncology, Departments of Internal Medicine, and Pharmacology, Yonsei University College of Medicine, Seoul 03722, Korea.
4
Microenvironment and Metastasis Laboratory, Department of Molecular Oncology, Spanish National Cancer Research Center (CNIO), Madrid 28029, Spain.
#
Contributed equally

Abstract

Tumor-secreted extracellular vesicles (EVs) are critical mediators of intercellular communication between tumor cells and stromal cells in local and distant microenvironments. Accordingly, EVs play an essential role in both primary tumor growth and metastatic evolution. EVs orchestrate multiple systemic pathophysiological processes, such as coagulation, vascular leakiness, and reprogramming of stromal recipient cells to support pre-metastatic niche formation and subsequent metastasis. Clinically, EVs may be biomarkers and novel therapeutic targets for cancer progression, particularly for predicting and preventing future metastatic development.

KEYWORDS:

cancer; exosomes; extracellular vesicles; intercellular communication; metastasis; microvesicles; pre-metastatic niche

PMID:
27960084
PMCID:
PMC5157696
DOI:
10.1016/j.ccell.2016.10.009
[Indexed for MEDLINE]
Free PMC Article

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