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Annu Rev Pathol. 2017 Jan 24;12:75-102. doi: 10.1146/annurev-pathol-052016-100208. Epub 2016 Dec 5.

Signaling and Immune Regulation in Melanoma Development and Responses to Therapy.

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Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts 02114.
Cutaneous Biology Research Center, Massachusetts General Hospital, Boston, Massachusetts 02114; email:


Melanoma is a complex and genomically diverse malignancy, and new genes and signaling pathways involved in pathogenesis continue to be discovered. Mechanistic insights into gene and immune regulation in melanoma have led to the development of numerous successful and innovative pharmacologic agents over recent years. Multiple targeted therapies and immunotherapies have already entered the clinic, becoming new standards of care and transforming the prognosis for many patients with malignant melanoma. In this review, we provide an overview of the current understanding of signaling and immune regulation in melanoma and implications for responses to treatment, organized in the framework of hallmark characteristics in cancer.


genomics; immunotherapy; melanocytes; pathogenesis; targeted therapy

[Indexed for MEDLINE]

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