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Support Care Cancer. 2017 Mar;25(3):1001-1011. doi: 10.1007/s00520-016-3521-7. Epub 2016 Dec 12.

Topical interventions to prevent acute radiation dermatitis in head and neck cancer patients: a systematic review.

Author information

1
Nursing Department, School of Health Sciences, University of Brasília, Darcy Ribeiro University Campus, Asa Norte, Brasilia, Federal District, Brazil. elaine.barrosf@gmail.com.
2
Nursing Department, School of Health Sciences, University of Brasília, Darcy Ribeiro University Campus, Asa Norte, Brasilia, Federal District, Brazil.
3
Hospital Sírio Libanês, Asa Sul, Brasília, DF, Brazil.
4
FACN Royal Brisbane and Women's Hospital, Metro North Hospital and Health Service, Queensland University of Technology, QLD, Kelvin Grove, 4059, Australia.
5
Federal University of Santa Catarina, Rua Engenheiro Agronômo Andrey Cristian Ferreira, Trindade, Florianópolis, Santa Catarina, Brazil.

Abstract

PURPOSE:

The purpose of the study is to evaluate the effects of pharmacological and non-pharmacological topical controls in the prevention of radiation dermatitis.

METHODS:

Relevant clinical trials were identified through electronic searching databases CINAHL, CENTRAL, LILACS, PubMed, Scopus, and Web of Science. Handsearching and gray literature searches were also performed to find additional references. Primary outcomes of interest were the development of radiation dermatitis and the time of occurrence of radiation dermatitis.

RESULTS:

Thirteen randomized clinical trials were included in this review. The trials were published in Chinese, English, or French, from 1980 to 2015. Pharmacological interventions used in the trials were trolamine, aloe vera, allantoin, Lianbai liquid, sucralfate, Na-sucrose octasulfate, olive oil, hialuronic acid, and dexpanthenol. Non-pharmacological topical controls were usual care/institution routine, aqueous cream, mild soap, water thermal gel, placebo, and no intervention.

CONCLUSIONS:

There was no strong evidence that indicates differences between topical pharmacological interventions or non-pharmacological topical controls in the prevention of acute radiation dermatitis among patients with head and neck cancer undergoing radiotherapy.

KEYWORDS:

Head and neck cancer; Radiodermatitis; Radiotherapy; Skin care

PMID:
27957620
DOI:
10.1007/s00520-016-3521-7
[Indexed for MEDLINE]

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