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Clin Microbiol Infect. 2017 Apr;23(4):267.e1-267.e4. doi: 10.1016/j.cmi.2016.12.003. Epub 2016 Dec 9.

Incidence and progression to cirrhosis of new hepatitis C virus infections in persons living with human immunodeficiency virus.

Collaborators (165)

d'Arminio Monforte A, Andreoni M, Angarano G, Antinori A, Castelli F, Cauda R, Di Perri G, Galli M, Iardino R, Ippolito G, Lazzarin A, Perno CF, von Schloesser F, Viale P, Castagna A, Ceccherini-Silberstein F, Cozzi-Lepri A, Girardi E, Lo Caputo S, Mussini C, Puoti M, Andreoni M, Ammassari A, Balotta C, Bandera A, Bonfanti P, Bonora S, Borderi M, Calcagno A, Calza L, Capobianchi MR, Castagna A, Ceccherini-Silberstein F, Cingolani A, Cinque P, De Luca A, Di Biagio A, Gianotti N, Gori A, Guaraldi G, Lapadula G, Lichtner M, Lo Caputo S, Madeddu G, Maggiolo F, Marchetti G, Marcotullio S, Monno L, Mussini C, Nozza S, Quiros Roldan E, Rossotti R, Rusconi S, Santoro MM, Saracino A, Zaccarelli M, Fanti I, Galli L, Lorenzini P, Rodano A, Shanyinde M, Tavelli A, Carletti F, Carrara S, Di Caro A, Graziano S, Petrone F, Prota G, Quartu S, Truffa S, Giacometti IA, Costantini A, Valeriani C, Angarano G, Monno L, Santoro C, Maggiolo F, Suardi C, Viale P, Donati V, Verucchi G, Castelli F, Quiros Roldan E, Minardi C, Quirino T, Abeli C, Manconi PE, Piano P, Cacopardo B, Celesia B, Vecchiet J, Falasca K, Sighinolfi L, Segala D, Mazzotta F, Vichi F, Cassola G, Viscoli C, Alessandrini A, Bobbio N, Mazzarello G, Mastroianni C, Belvisi V, Bonfanti P, Caramma I, Chiodera A, Castelli AP, Galli M, Lazzarin A, Rizzardini G, Ridolfo AL, Piolini R, Castagna A, Salpietro S, Carenzi L, Moioli MC, Tincati C, Marchetti G, Mussini C, Puzzolante C, Lapadula G, Abrescia N, Chirianni A, Borgia G, Di Martino F, Maddaloni L, Gentile I, Orlando R, Baldelli F, Francisci D, Parruti G, Ursini T, Magnani G, Ursitti MA, Cauda R, Andreoni M, Vullo V, Cristaudo A, Cingolani A, Baldin G, Cicalini S, Gallo L, Nicastri E, Acinapura R, Capozzi M, Libertone R, Savinelli S, Latini A, Iaiani G, Fontanelli Sulekova L, Cecchetto M, Viviani F, Mura MS, Madeddu G, De Luca A, Rossetti B, Caramello P, Di Perri G, Orofino GC, Bonora S, Sciandra M, Bassetti M, Londero A, Pellizzer G, Manfrin V.

Author information

1
Division of Infectious Diseases, Niguarda Cà Granda Hospital, Milano, Italy.
2
Clinical Department and Department of Epidemiology, National Institute for Infectious Diseases, "Lazzaro Spallanzani", Rome, Italy.
3
Hampstead Department of Infection & Population Health, University College London, London, UK.
4
Division of Infectious Diseases, San Gerardo Hospital, Monza, Italy.
5
Division of Infectious Diseases "La Sapienza" Rome University Polo Pontino, Latina, Italy.
6
Department of Infectious Diseases, Luigi Sacco Hospital, Milan, Italy.
7
Department of Infectious Diseases and Tropical Medicine, University of Genoa, San Martino Hospital, Genova, Italy.
8
Department of Health Sciences, Clinic of Infectious Diseases, San Paolo Hospital, University of Milano, Milano Italy.
9
Clinical Department and Department of Epidemiology, National Institute for Infectious Diseases, "Lazzaro Spallanzani", Rome, Italy. Electronic address: enrico.girardi@inmi.it.

Abstract

OBJECTIVE:

To estimate the incidence of hepatitis C virus (HCV) seroconversion and the risk of severe fibrosis/cirrhosis in HCV seroconverters among persons with human immunodeficiency virus (HIV) infection.

METHODS:

We analysed data on 4059 persons with HIV enrolled in a cohort study in Italy.

RESULTS:

Incidence rate of seroconversion was 0.6/100 person-years overall, and drug users and men-who-have-sex-with-men were at highest risk. The cumulative risk of progression to severe fibrosis/cirrhosis was 30% by 10 years after seroconversion.

CONCLUSIONS:

New HCV infections have a rapidly progressive course in this population. Persons with HIV and HCV superinfection should be prioritized for treatment with anti-HCV direct-acting antivirals.

KEYWORDS:

Cirrhosis; Cohort study; Hepatitis C virus; Human immunodeficiency virus; Incidence

PMID:
27956268
DOI:
10.1016/j.cmi.2016.12.003
[Indexed for MEDLINE]
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