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Dent Mater. 2017 Mar;33(3):e115-e123. doi: 10.1016/j.dental.2016.11.008. Epub 2016 Dec 10.

Silver doped titanium dioxide nanoparticles as antimicrobial additives to dental polymers.

Author information

1
Child Dental Health, School of Oral and Dental Sciences, University of Bristol, Lower Maudlin Street, Bristol BS1 2LY, United Kingdom.
2
Musgrove Park Hospital, Taunton TA1 5DA, United Kingdom.
3
Biomaterials Engineering, School of Oral and Dental Sciences, University of Bristol, Lower Maudlin Street, Bristol BS1 2LY, United Kingdom.
4
Oral Microbiology, School of Oral and Dental Sciences, University of Bristol Lower Maudlin Street, Bristol, BS1 2LY, United Kingdom.
5
Child Dental Health, School of Oral and Dental Sciences, University of Bristol, Lower Maudlin Street, Bristol BS1 2LY, United Kingdom. Electronic address: tony.ireland@bristol.ac.uk.

Abstract

OBJECTIVE:

The objectives of this in vitro study were to produce a filled resin containing Ag-TiO2 filler particles and to test its antibacterial properties.

METHODS:

Ag-TiO2 particles were manufactured using the ball milling method and incorporated into an epoxy resin using a high speed centrifugal mixer. Using UV/vis spectrophotometry investigations were performed to assess how the photocatalytic properties of the Ag-TiO2 particles are affected when encased in resin. Adopting the bacteria colony counting technique, the antibacterial properties of Ag-TiO2 particles and Ag-TiO2 containing resins were assessed using Streptococcus mutans under varying lighting conditions.

RESULTS:

Ag doping of TiO2 results in a band gap shift towards the visible spectrum enabling Ag-TiO2 to exhibit photocatalytic properties when exposed to visible light. Small quantities of Ag-TiO2 were able to produce a bactericidal effect when in contact with S. mutans under visible light conditions. When incorporated into the bulk of an epoxy resin, the photocatalytic properties of the Ag-TiO2 particles were significantly reduced. However, a potent bactericidal effect was still achieved against S. mutans.

SIGNIFICANCE:

Ag-TiO2 filled resin shows promising antimicrobial properties, which could potentially be used clinically.

KEYWORDS:

Antimicrobial; Resin; Silver doped titanium oxide

PMID:
27955917
DOI:
10.1016/j.dental.2016.11.008
[Indexed for MEDLINE]

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