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Curr Opin Virol. 2017 Feb;22:36-43. doi: 10.1016/j.coviro.2016.11.012. Epub 2016 Dec 9.

Protect this house: cytosolic sensing of viruses.

Author information

1
Department of Molecular Genetics & Microbiology, Duke University Medical Center Durham, NC 27710, USA.
2
Department of Molecular Genetics & Microbiology, Duke University Medical Center Durham, NC 27710, USA; Department of Medicine, Duke University Medical Center Durham, NC 27710, USA. Electronic address: stacy.horner@duke.edu.

Abstract

The ability to recognize invading viral pathogens and to distinguish their components from those of the host cell is critical to initiate the innate immune response. The efficiency of this detection is an important factor in determining the susceptibility of the cell to viral infection. Innate sensing of viruses is, therefore, an indispensable step in the line of defense for cells and organisms. Recent discoveries have uncovered novel sensors of viral components and hallmarks of infection, as well as mechanisms by which cells discriminate between self and non-self. This review highlights the mechanisms used by cells to detect viral pathogens in the cytosol, and recent advances in the field of cytosolic sensing of viruses.

PMID:
27951430
PMCID:
PMC5346041
DOI:
10.1016/j.coviro.2016.11.012
[Indexed for MEDLINE]
Free PMC Article

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