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Exp Dermatol. 2017 Aug;26(8):744-747. doi: 10.1111/exd.13268. Epub 2017 Mar 23.

Galanin contributes to ultraviolet irradiation-induced inflammation in human skin.

Lee MJ1,2,3, Oh JH1,2,3, Park CH1,2,3, Kim KH1,2,3, Lee DH1,2,3, Chung JH1,2,3,4.

Author information

1
Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.
2
Laboratory of Cutaneous Aging Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea.
3
Institute of Human-Environment Interface Biology, Medical Research Center, Seoul National University, Seoul, Korea.
4
Institute on Aging, Seoul National University, Seoul, Korea.

Abstract

Exposure of the skin to ultraviolet (UV) irradiation causes various consequences such as inflammation and photoageing. Galanin is an active neuropeptide expressed widely in the central nervous system and peripheral tissues including the skin. Galanin promotes or inhibits inflammation in a context-dependent manner, but its role in UV irradiation-induced responses in human skin was still unknown. UV irradiation induced a substantial expression of galanin in primary epidermal keratinocytes in vitro and in human epidermis in vivo. Galanin knock-down by siRNA transfection markedly inhibited UV irradiation-induced expression of matrix metalloproteinase (MMP)-1, interleukin (IL)-1β, IL-6 and cyclooxygenase (COX)-2. Moreover, siRNA-mediated knock-down of GAL2 , a principal galanin receptor in the skin, led to a considerable decrease in these mediators in keratinocytes. Collectively, our findings suggest that galanin is an important messenger between the neuroendocrine system and UV irradiation-damaged skin.

KEYWORDS:

galanin; inflammation; ultraviolet

PMID:
27943416
DOI:
10.1111/exd.13268
[Indexed for MEDLINE]

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