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Quant Imaging Med Surg. 2016 Oct;6(5):486-489.

The 2016 World Health Organization Classification of tumours of the Central Nervous System: what the paediatric neuroradiologist needs to know.

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Department of Radiology, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK.
Developmental Biology and Cancer Programme, UCL Great Ormond Street Institute of Child Heath, London, UK.
Department of Pathology, Great Ormond Street Hospital NHS Foundation Trust, London, UK.


The recently published 2016 World Health Organization (WHO) classification of tumours of the Central Nervous System (CNS) introduces a number of significant changes from the previous edition. Based on an improved understanding of the genetic and molecular basis of tumorigenesis there has been a shift towards defining tumours by means of these characteristics in addition to their histological features, thus providing an integrated diagnosis. In this article, we will provide a concise overview of the salient changes in the 2016 WHO classification of tumours of the CNS that are of relevance to the paediatric neuroradiologist when it comes to day-to-day reporting.


Central nervous system neoplasms; World Health Organization (WHO); classification, diagnostic imaging; paediatric

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