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Appl Transl Genom. 2013 Feb 26;2:34-40. eCollection 2013 Dec 1.

Practical, ethical and regulatory considerations for the evolving medical and research genomics landscape.

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Stanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory, NY, United States; Utah Foundation for Biomedical Research, Salt Lake City, UT, United States.
New York Genome Center, New York City, NY, United States.


Recent advances in sequencing technology are making possible the application of large-scale genomic analyses to individualized care, both in wellness and disease. However, a number of obstacles remain before genomic sequencing can become a routine part of clinical practice. One of the more significant and underappreciated is the lack of consensus regarding the proper environment and regulatory structure under which clinical genome sequencing and interpretation should be performed. The continued reliance on pure research vs. pure clinical models leads to problems for both research participants and patients in an era in which the lines between research and clinical practice are becoming increasingly blurred. Here, we discuss some of the ethical, regulatory and practical considerations that are emerging in the field of genomic medicine. We also propose that many of the cost and safety issues we are facing can be mitigated through expanded reliance on existing clinical regulatory frameworks and the implementation of distributive work-sharing strategies designed to leverage the strengths of our genomics centers and clinical interpretive teams.


CLIA; CLIA, Clinical Laboratory Improvements Amendments; Ethics; Exome; Genetic testing; Genomics; NGS, Next generation sequencing; Regulation; WGS, whole-genome sequencing; Whole genome sequencing

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