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J Card Fail. 2017 May;23(5):363-369. doi: 10.1016/j.cardfail.2016.12.003. Epub 2016 Dec 8.

Obesity in Middle Age Increases Risk of Later Heart Failure in Women-Results From the Prospective Population Study of Women and H70 Studies in Gothenburg, Sweden.

Author information

1
Department of Primary Health Care, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
2
Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
3
Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Institute of Health and Care Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
4
Section for Epidemiology and Social Medicine (EPSO), Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
5
Department of Primary Health Care, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden. Electronic address: cecilia.bjorkelund@allmed.gu.se.

Abstract

OBJECTIVE:

Obesity has been shown to be a risk factor for heart failure (HF), but whether the association varies by age is not understood. The aim was to examine the impact of obesity/overweight on the risk of developing heart failure in women of different ages by analysing prospective data from 2 population studies.

METHODS:

Data were obtained from the Population Study of Women in Gothenburg and the Gerontologic and Geriatric Population Studies concerning body mass index (BMI) collected in 1980 or later. Follow-up ended in 2006. Cox proportional hazard methods were used to determine associations between developing HF and BMI in 2574 women, 1243 aged 26-65 years and 1331 aged 66-76 years, at baseline.

RESULTS:

Women aged 26-65 years at baseline with BMI ≥30 kg/m2 had an increased risk of developing HF (hazard ratio [HR] 2.61, 95% confidence interval [CI] 1.56-4.35) even when controlling for age, glucose, smoking, alcohol consumption, serum triglycerides, and systolic blood pressure (reference group: women with BMI 18.5-22.4 kg/m2). Obese women aged 66-76 years at baseline did not show increased risk of developing HF (HR 0.55, 95% CI 0.23-1.29).

CONCLUSIONS:

Obesity in middle-age women increases their risk of developing HF later in life. In contrast, obesity later in life shows no association with HF.

KEYWORDS:

Obesity; heart failure; longitudinal study; women

PMID:
27940334
DOI:
10.1016/j.cardfail.2016.12.003
[Indexed for MEDLINE]

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