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Biochim Biophys Acta. 2017 Nov;1862(11):1424-1438. doi: 10.1016/j.bbalip.2016.11.014. Epub 2016 Dec 9.

Structure, inhibition, and regulation of essential lipid A enzymes.

Author information

1
Department of Biochemistry, Duke University Medical Center, Research Drive, DUMC 3711, Durham, NC 27710, USA. Electronic address: peizhou@biochem.duke.edu.
2
Department of Biochemistry, Duke University Medical Center, Research Drive, DUMC 3711, Durham, NC 27710, USA.

Abstract

The Raetz pathway of lipid A biosynthesis plays a vital role in the survival and fitness of Gram-negative bacteria. Research efforts in the past three decades have identified individual enzymes of the pathway and have provided a mechanistic understanding of the action and regulation of these enzymes at the molecular level. This article reviews the discovery, biochemical and structural characterization, and regulation of the essential lipid A enzymes, as well as continued efforts to develop novel antibiotics against Gram-negative pathogens by targeting lipid A biosynthesis. This article is part of a Special Issue entitled: Bacterial Lipids edited by Russell E. Bishop.

PMID:
27940308
PMCID:
PMC5466501
[Available on 2018-11-01]
DOI:
10.1016/j.bbalip.2016.11.014
[Indexed for MEDLINE]

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