Format

Send to

Choose Destination
Curr Opin Insect Sci. 2016 Dec;18:11-16. doi: 10.1016/j.cois.2016.08.007. Epub 2016 Aug 24.

Embryonic axon guidance: insights from Drosophila and other insects.

Author information

1
Department of Biological Sciences, University of Arkansas, Fayetteville, AR 72701, United States. Electronic address: evanst@uark.edu.

Abstract

During embryonic development, growing axons are guided by cellular signaling pathways that control a series of individual axon guidance decisions. In Drosophila, two major pathways (Netrin-Frazzled/DCC and Slit-Robo) regulate axon guidance in the embryonic ventral nerve cord, including the critical decision of whether or not to cross the midline. Studies in the fruit fly have revealed a complex picture of precise regulation and cross-talk between these pathways. In addition, Robo receptors in Drosophila have diversified their activities to regulate additional axon guidance decisions in the developing embryo. Here, I discuss recent advances in understanding roles and regulation of the Net-Fra and Slit-Robo signaling pathways in Drosophila, and examine the evolutionary conservation of these signaling mechanisms across insects and other arthropods.

PMID:
27939705
DOI:
10.1016/j.cois.2016.08.007
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center