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Trends Immunol. 2017 Feb;38(2):94-103. doi: 10.1016/ Epub 2016 Dec 9.

Transcriptional Regulation of Tissue-Resident Lymphocytes.

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Department of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia. Electronic address:
Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.


Numerous innate and adaptive immune cells reside in non-lymphoid tissues, where they contribute to barrier immunity, tissue homeostasis, and immune regulation. These tissue-resident populations do not recirculate in the blood or lymphatics and adopt a unique phenotype that is distinct from immune cells in the circulation. Tissue residency has been predominantly described for memory CD8+ T cells [tissue-resident memory T cells (TRM)], but it is now clear that CD4 T cells, regulatory T (Treg) cells, various innate T cells, and innate lymphoid cells (ILCs) can establish residence in non-lymphoid tissues. Here we highlight distinct and common features of tissue-resident lymphocytes, with a focus on the transcriptional programs that have recently been shown to guide the establishment of tissue residency.

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