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Pharm Biol. 2017 Dec;55(1):497-502.

Hypocholesterolemic efficacy of royal jelly in healthy mild hypercholesterolemic adults.

Author information

1
a Department of Chinese Medicine , Taichung Hospital, Ministry of Health and Well-being , Taichung City , Taiwan, ROC.
2
b School of Nutrition, Chung Shan Medical University , Taichung City , Taiwan, ROC.
3
c Department of Neurology , Chung Shan Medical University , Taichung City , Taiwan, ROC.
4
d School of Health Diet and Industry Management, Chung Shan Medical University , Taichung City , Taiwan, ROC.
5
e ITMO University , Saint-Petersburg , Russia.

Abstract

CONTEXT:

Royal jelly (RJ) has been reported for its health promoting factors such as antioxidant, anti-inflammatory and lipid lowering activities.

OBJECTIVE:

The present randomized, placebo-controlled study examines the hypolipidemic beneficial effect of RJ through evaluating anthropometric measurements, lipid profile and various hormone levels in mildly hypercholesterolemic participants.

MATERIALS AND METHODS:

Forty subjects with mild hypercholesterolemia (180-200 mg/dL) were randomly selected and divided into two groups as experimental or placebo, who requested to intake nine capsules (350 mg/capsule) of RJ or placebo/day, respectively, for three months with one month of follow-up without any supplementation.

RESULTS:

No significant changes were noted in any of the anthropometric parameters like body weight, waist and body fat. The serum total cholesterol (TC; 207.05-183.15 mg/dL) and low-density lipoprotein cholesterol (LDL-c; 126.44-120.31 mg/dL) levels were reduced significantly (p < 0.05) after administration of RJ. However, triglyceride (TG) and high-density lipoprotein cholesterol (HDL-c) levels were not considerably altered. Moreover, three months of RJ consumption significantly ameliorated (p < 0.05) the concentration of sex hormones like dehydroepiandrosterone sulphate (DHEA-S; 1788.09-1992.31 ng/mL). Also, intake of RJ did not elicit any hepatic or renal damage.

DISCUSSION AND CONCLUSION:

Intervention with RJ for three months considerably lowered the TC and LDL-c levels through improving the levels of DHEA-S and thus alleviates the risk of cardiovascular disease (CVD).

KEYWORDS:

Lipids; cardiovascular disease; dehydroepiandrosterone sulphate; hypercholesterolemia; royal jelly

PMID:
27937077
PMCID:
PMC6130454
DOI:
10.1080/13880209.2016.1253110
[Indexed for MEDLINE]
Free PMC Article

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