Format

Send to

Choose Destination
Muscle Nerve. 2017 Aug;56(2):264-270. doi: 10.1002/mus.25508. Epub 2017 Mar 29.

Exercise responses in patients with chronically high creatine kinase levels.

Author information

1
UCLA Exercise Physiology Research Laboratory, Department of Medicine, David Geffen School of Medicine, University of California, 10833 Le Conte Avenue, 37-131 CHS, Los Angeles, 90095, USA.
2
Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, USA.
3
Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, USA.
4
Cambridge University Sports & Exercise Medicine Unit, Addenbrooke's Hospital, Cambridge, England.
5
Queen's University, Belfast, Northern Ireland, UK.

Abstract

INTRODUCTION:

Elevated serum creatine kinase (CK) is often taken to reflect muscle disease, but many individuals have elevated CK without a specific diagnosis. How elevated CK reflects muscle metabolism during exercise is not known.

METHODS:

Participants (46 men, 48 women) underwent incremental exercise testing to assess aerobic performance, cardiovascular response, and ventilatory response. Serum lactate, ammonia, and CK were measured at rest, 4 minutes into exercise, and 2 minutes into recovery.

RESULTS:

High-CK and control subjects demonstrated similar aerobic capacities and cardiovascular responses to incremental exercise. Those with CK ≥ 300 U/L exhibited significantly higher lactate and ammonia levels after maximal exercise, together with increased ventilatory responses, whereas those with CK ≥200 U/L but ≤ 300 U/L did not.

CONCLUSIONS:

We recommend measurement of lactate and ammonia profiles during a maximal incremental exercise protocol to help identify patients who warrant muscle biopsy to rule out myopathy. Muscle Nerve 56: 264-270, 2017.

KEYWORDS:

ammonia; creatine kinase; exercise testing; lactate; myopathy

PMID:
27935086
DOI:
10.1002/mus.25508
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center