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Indian J Med Microbiol. 2016 Oct-Dec;34(4):506-508. doi: 10.4103/0255-0857.195351.

Synergism between fluconazole and methylene blue-photodynamic therapy against fluconazole-resistant Candida strains.

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  • 1Department of Natural Sciences, Campus Centro-Oeste D. Lindu, Universidade Federal de São João Del Rei, São João Del Rei, São Paulo, Brazil.
  • 2Department of Animal Science, Instituto de Engenharia Biomédica, Universidade Camilo Castelo Branco, São Paulo, Brazil.


Photodynamic therapy (PDT) has been proved to be effective against fungi and it may be employed as a coadjutant to conventional antifungal agents, leading to a more effective microbial control minimising side effects. This work evaluates the combined effect of PDT and fluconazole against resistant Candida albicans, Candida glabrata and Candida krusei. The yeasts were submitted to methylene blue-PDT (MB-PDT) in sub-inhibitory concentrations. In the present work, MB-PDT combined with fluconazole was more efficient in the inhibition of the C. albicans and C. glabrata than each treatment alone, being possible to infer that the treatments are synergic.

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