Format

Send to

Choose Destination
Science. 2016 Dec 2;354(6316):1140-1144.

Selective modulation of cortical state during spatial attention.

Author information

1
Departments of Bioengineering and Electrical Engineering, Stanford University, Stanford, CA, USA. tatiana.engel@stanford.edu.
2
Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA.
3
Department of Neurobiology, Stanford University, Stanford, CA, USA.
4
Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.
5
Departments of Bioengineering and Electrical Engineering, Stanford University, Stanford, CA, USA.

Abstract

Neocortical activity is permeated with endogenously generated fluctuations, but how these dynamics affect goal-directed behavior remains a mystery. We found that ensemble neural activity in primate visual cortex spontaneously fluctuated between phases of vigorous (On) and faint (Off) spiking synchronously across cortical layers. These On-Off dynamics, reflecting global changes in cortical state, were also modulated at a local scale during selective attention. Moreover, the momentary phase of local ensemble activity predicted behavioral performance. Our results show that cortical state is controlled locally within a cortical map according to cognitive demands and reveal the impact of these local changes in cortical state on goal-directed behavior.

PMID:
27934763
DOI:
10.1126/science.aag1420
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center