Format

Send to

Choose Destination
Org Lett. 2016 Nov 18;18(22):5904-5907. Epub 2016 Nov 10.

Garmultins A-G, Biogenetically Related Polycyclic Acylphloroglucinols from Garcinia multiflora.

Author information

1
The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences , Guiyang 550002, P. R. China.
2
Guizhou University , Guiyang 550025, P. R. China.
3
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, P. R. China.

Abstract

Garmultins A and B (1 and 2), two polycyclic polyprenylated acylphloroglucinols characterized by the coupling of two novel cages, 2,11-dioxatricyclo[4.4.1.03,9]undecane and tricyclo[4.3.1.03,7]decane, along with five biogenetically related analogues (3-7), were isolated from Garcinia multiflora. Their structures and absolute configurations were determined by extensive NMR analysis, X-ray crystallography, and electronic circular dichroism calculations. Three compounds were capable of inhibiting oncogene expression and inducing apoptosis in human erythroleukemia cells.

PMID:
27934507
DOI:
10.1021/acs.orglett.6b03004
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for American Chemical Society
Loading ...
Support Center