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J Org Chem. 2016 Dec 2;81(23):12038-12045. Epub 2016 Nov 18.

Rhodium-Catalyzed Oxidative Synthesis of Quinoline-Fused Sydnones via 2-fold C-H Bond Activation.

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1
Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023, China.

Abstract

Rh(III)-catalyzed synthesis of mesoionic heterocycles has been achieved via C-H activation of sydnones and oxidative coupling with internal alkynes. This reaction occurred under mild conditions with high efficiency, broad substrate scope, and low catalyst loading. Moreover, synthetic applications of a coupled product have been demonstrated in the late-stage derivatization into a variety of highly functionalized scaffolds.

PMID:
27934467
DOI:
10.1021/acs.joc.6b02356

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