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J Org Chem. 2016 Dec 2;81(23):11548-11555. Epub 2016 Nov 15.

Recent Developments in Amide Synthesis Using Nonactivated Starting Materials.

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1
Laboratory of Organic Synthesis, Bio and Organocatalysis, Chemistry Department, Universidad de los Andes , Cra 1 No. 18A-12 Q:305, Bogotá 111711, Colombia.

Abstract

Amides are unquestionably one of the most important functional groups in organic chemistry because of their presence in numerous interesting molecules such as peptides, pharmaceutical agents, naturally occurring molecules, proteins and alkaloids, among others. This synopsis surveys the diverse recent approaches to amide synthesis from nonactivated carboxylic acids and derivatives as well as noncarboxylic compounds, highlighting the most innovative methodologies and those that are more eco-friendly compared to traditional methods while focusing on recent developments during the past two years.

PMID:
27934465
DOI:
10.1021/acs.joc.6b02358

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