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Lab Anim. 2017 Aug;51(4):388-396. doi: 10.1177/0023677216680238. Epub 2016 Dec 8.

Computed tomography-based survey of the vascular anatomy of the juvenile Göttingen minipig.

Author information

1
1 Department of Surgery, Campus Charité Mitte | Campus Virchow-Klinikum, Experimental Surgery and Regenerative Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.
2
2 Department of Diagnostic and Interventional Radiology, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum, Berlin, Germany.
3
3 BIH-Charité Clinican Scientist Program, Berlin Institute of Health (BIH), Berlin, Germany.
4
4 Department of Experimental Medicine, Charité - Universitaütsmedizin Berlin, Berlin, Germany.
5
5 Department of Anaesthesiology and Intensive Care Medicine, University Hospital Leipzig, Leipzig, Germany.

Abstract

Over the past 50 years, image-guided procedures have been established for a wide range of applications. The development and clinical translation of new treatment regimens necessitate the availability of suitable animal models. The juvenile Göttingen minipig presents a favourable profile as a model for human infants. However, no information can be found regarding the vascular system of juvenile minipigs in the literature. Such information is imperative for planning the accessibility of target structures by catheterization. We present here a complete mapping of the arterial system of the juvenile minipig based on contrast-enhanced computed tomography. Four female animals weighing 6.13 ± 0.72 kg were used for the analyses. Imaging was performed under anaesthesia, and the measurement of the vascular structures was performed independently by four investigators. Our dataset forms a basis for future interventional studies in juvenile minipigs, and enables planning and refinement of future experiments according to the 3R (replacement, reduction and refinement) principles of animal research.

KEYWORDS:

3Rs; animal model; circulatory physiology; pigs

PMID:
27932686
DOI:
10.1177/0023677216680238
[Indexed for MEDLINE]

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