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Crit Rev Oncol Hematol. 2016 Dec;108:137-145. doi: 10.1016/j.critrevonc.2016.11.004. Epub 2016 Nov 15.

The role of the IGF-1 Ec in myoskeletal system and osteosarcoma pathophysiology.

Author information

1
Physiology Laboratory, Athens Medical School, National and Kapodestrian University of Athens, Greece; Third orthopaedic clinic, KAT General Hospital, Kifisia, Attiki, Greece. Electronic address: narmakolas@gmail.com.
2
Physiology Laboratory, Athens Medical School, National and Kapodestrian University of Athens, Greece. Electronic address: aarmakol@med.uoa.gr.
3
Third orthopaedic clinic, KAT General Hospital, Kifisia, Attiki, Greece. Electronic address: thanosarmakolas@yahoo.com.
4
Physiology Laboratory, Athens Medical School, National and Kapodestrian University of Athens, Greece. Electronic address: dhmakak@med.uoa.gr.
5
Physiology Laboratory, Athens Medical School, National and Kapodestrian University of Athens, Greece. Electronic address: stathakimg@yahoo.gr.
6
Physiology Laboratory, Athens Medical School, National and Kapodestrian University of Athens, Greece. Electronic address: mkoutsil@med.uoa.gr.

Abstract

Growth hormone (GH) regulated mainly liver-produced insulin-like growth factor 1 (IGF-1) is a key molecule in embryonic & post embryonic development that is also involved in cancer biology. Herein we review new insights of the role of igf-1 gene products and of the IGF-1Ec isoform in muscle and bone development/repair and its role in osteosarcoma pathophysiology, underlying the possible role of the Ec peptide as a future therapeutic target.

KEYWORDS:

Bone; Ec peptide; IGF-1; IGF-1Ec; IGF-1R; Muscle repair; Osteosarcoma

[Indexed for MEDLINE]

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