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Trends Genet. 2017 Jan;33(1):58-67. doi: 10.1016/j.tig.2016.11.002. Epub 2016 Dec 5.

A Magic Spot in Genome Maintenance.

Author information

1
Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA; Howard Hughes Medical Institute, New York University School of Medicine, New York, NY 10016, USA.
2
Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA.
3
Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA; Howard Hughes Medical Institute, New York University School of Medicine, New York, NY 10016, USA. Electronic address: evgeny.nudler@nyumc.org.

Abstract

Nucleotide excision repair (NER) is the key DNA repair system that eliminates the majority of DNA helix-distorting lesions. RNA polymerase (RNAP) expedites the recognition of DNA damage by NER components via transcription-coupled DNA repair (TCR). In bacteria, a modified nucleotide ppGpp ('magic spot') is a pleiotropic second messenger that mediates the response to nutrient deficiencies by altering the initiation properties of RNAP. In this review, we discuss newly elucidated roles of guanosine 5'-diphosphate 3'-diphosphate (ppGpp) in transcription elongation that couple this alarmone to DNA damage repair and maintenance.

KEYWORDS:

DNA repair; backtracking; mutation rate; ppGpp; transcription elongation

PMID:
27931778
PMCID:
PMC5182163
DOI:
10.1016/j.tig.2016.11.002
[Indexed for MEDLINE]
Free PMC Article

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