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Gynecol Oncol. 2017 Feb;144(2):405-413. doi: 10.1016/j.ygyno.2016.10.019. Epub 2016 Dec 6.

The histology of ovarian cancer: worldwide distribution and implications for international survival comparisons (CONCORD-2).

Collaborators (494)

Bouzbid S, Hamdi-Chérif M, Zaidi Z, Bah E, Swaminathan R, Nortje SH, Stefan DC, El Mistiri MM, Bayo S, Malle B, Manraj SS, Sewpaul-Sungkur R, Fabowale A, Ogunbiyi OJ, Bradshaw D, Somdyala NIM, Abdel-Rahman M, Jaidane L, Mokni M, Kumcher I, Moreno F, González MS, Laura EA, Espinola SB, Calabrano GH, Carballo Quintero B, Fita R, Garcilazo DA, Giacciani PL, Diumenjo MC, Laspada WD, Green MA, Lanza MF, Ibañez SG, Lima CA, Lobo de Oliveira E, Daniel C, Scandiuzzi C, De Souza PCF, Melo CD, Del Pino K, Laporte C, Curado MP, de Oliveira JC, Veneziano CLA, Veneziano DB, Alexandre TS, Verdugo AS, Azevedo E Silva G, Galaz JC, Moya JA, Herrmann DA, Vargas S, Herrera VM, Uribe CJ, Bravo LE, Arias-Ortiz NE, Jurado DM, Yépez MC, Galán YH, Torres P, Martínez-Reyes F, Pérez-Meza ML, Jaramillo L, Quinto R, Cueva P, Yépez JG, Torres-Cintrón CR, Tortolero-Luna G, Alonso R, Barrios E, Nikiforuk C, Shack L, Coldman AJ, Woods RR, Noonan G, Turner D, Kumar E, Zhang B, McCrate FR, Ryan S, Hannah H, Dewar RAD, MacIntyre M, Lalany A, Ruta M, Marrett L, Nishri DE, McClure C, Vriends KA, Bertrand C, Louchini R, Robb KI, Stuart-Panko H, Demers S, Wright S, George JT, Shen X, Brockhouse JT, O'Brien DK, Ward KC, Almon L, Bates J, Rycroft R, Mueller L, Phillips C, Brown H, Cromartie B, Schwartz AG, Vigneau F, MacKinnon JA, Wohler B, Bayakly AR, Clarke CA, Glaser SL, West D, Green MD, Hernandez BY, Johnson CJ, Jozwik D, Charlton ME, Lynch CF, Huang B, Tucker TC, Deapen D, Liu L, Hsieh MC, Wu XC, Stern K, Gershman ST, Knowlton RC, Alverson J, Copeland GE, Rogers DB, Lemons D, Williamson LL, Hood M, Hosain GM, Rees JR, Pawlish KS, Stroup A, Key C, Wiggins C, Kahn AR, Schymura MJ, Leung G, Rao C, Giljahn L, Warther B, Pate A, Patil M, Schubert SS, Rubertone JJ, Slack SJ, Fulton JP, Rousseau DL, Janes TA, Schwartz SM, Bolick SW, Hurley DM, Richards J, Whiteside MA, Nogueira LM, Herget K, Sweeney C, Martin J, Wang S, Harrelson DG, Keitheri Cheteri MB, Farley S, Hudson AG, Borchers R, Stephenson L, Espinoza JR, Weir HK, Edwards BK, Wang N, Yang L, Chen JS, Song GH, Gu XP, Zhang P, Ge HM, Zhao DL, Zhang JH, Zhu FD, Tang JG, Shen Y, Wang J, Li QL, Yang XP, Dong J, Li W, Cheng LP, Chen JG, Huang QH, Huang SQ, Guo GP, Wei K, Chen WQ, Zeng H, Demetriou AV, Pavlou P, Mang WK, Ngan KC, Swaminathan R, Kataki AC, Krishnatreya M, Jayalekshmi PA, Sebastian P, Sapkota SD, Verma Y, Nandakumar A, Suzanna E, Keinan-Boker L, Silverman BG, Ito H, Nakagawa H, Hattori M, Kaizaki Y, Sugiyama H, Utada M, Katayama K, Narimatsu H, Kanemura S, Koike T, Miyashiro I, Yoshii M, Oki I, Shibata A, Matsuda T, Nimri O, Ab Manan A, Bhoo Pathy N, Chimedsuren O, Tuvshingerel S, Al Khater AHM, El Mistiri MM, Al-Eid H, Jung KW, Won YJ, Chiang CJ, Lai MS, Suwanrungruang K, Wiangnon S, Daoprasert K, Pongnikorn D, Geater SL, Sriplung H, Eser S, Yakut CI, Hackl M, Mühlböck H, Oberaigner W, Zborovskaya AA, Aleinikova OV, Henau K, Van Eycken L, Dimitrova N, Valerianova Z, Šekerija M, Zvolský M, Engholm G, Storm H, Innos K, Mägi M, Malila N, Seppä K, Jégu J, Velten M, Cornet E, Troussard X, Bouvier AM, Faivre J, Guizard AV, Bouvier V, Launoy G, Arveux P, Maynadié M, Mounier M, Fournier E, Woronoff AS, Daoulas M, Clavel J, Le Guyader-Peyrou S, Monnereau A, Trétarre B, Colonna M, Cowppli-Bony A, Molinié F, Bara S, Degré D, Ganry O, Lapôtre-Ledoux B, Grosclaude P, Estève J, Bray F, Piñeros M, Sassi F, Stabenow R, Eberle A, Erb C, Nennecke A, Kieschke J, Sirri E, Kajueter H, Emrich K, Zeissig SR, Holleczek B, Eisemann N, Katalinic A, Brenner H, Asquez RA, Kumar V, Ólafsdóttir EJ, Tryggvadóttir L, Comber H, Walsh PM, Sundseth H, Devigili E, Mazzoleni G, Giacomin A, Bella F, Castaing M, Sutera A, Gola G, Ferretti S, Serraino D, Zucchetto A, Lillini R, Vercelli M, Busco S, Pannozzo F, Vitarelli S, Ricci P, Pascucci C, Autelitano M, Cirilli C, Federico M, Fusco M, Vitale MF, Usala M, Cusimano R, Mazzucco W, Michiara M, Sgargi P, Maule MM, Sacerdote C, Tumino R, Di Felice E, Vicentini M, Falcini F, Cremone L, Budroni M, Cesaraccio R, Contrino ML, Tisano F, Fanetti AC, Maspero S, Candela G, Scuderi T, Gentilini MA, Piffer S, Rosso S, Sacchetto L, Caldarella A, La Rosa F, Stracci F, Contiero P, Tagliabue G, Dei Tos AP, Zorzi M, Zanetti R, Baili P, Berrino F, Gatta G, Sant M, Capocaccia R, De Angelis R, Liepina E, Maurina A, Smailyte G, Agius D, Calleja N, Siesling S, Visser O, Larønningen S, Møller B, Dyzmann-Sroka A, Trojanowski M, Góźdż S, Mężyk R, Grądalska-Lampart M, Radziszewska AU, Didkowska JA, Wojciechowska U, Błaszczyk J, Kępska K, Bielska-Lasota M, Kwiatkowska K, Forjaz G, Rego RA, Bastos J, Silva MA, Antunes L, Bento MJ, Mayer-da-Silva A, Miranda A, Coza D, Todescu AI, Valkov MY, Adamcik J, Safaei Diba C, Primic-Žakelj M, Žagar T, Stare J, Almar E, Mateos A, Quirós JR, Bidaurrazaga J, Larrañaga N, Díaz García JM, Marcos AI, Marcos-Gragera R, Vilardell Gil ML, Molina E, Sánchez MJ, Franch Sureda P, Ramos Montserrat M, Chirlaque MD, Navarro C, Ardanaz EE, Moreno-Iribas CC, Fernández-Delgado R, Peris-Bonet R, Galceran J, Khan S, Lambe M, Camey B, Bouchardy C, Usel M, Ess SM, Herrmann C, Bulliard JL, Maspoli-Conconi M, Frick H, Kuehni CE, Schindler M, Bordoni A, Spitale A, Chiolero A, Konzelmann I, Dehler SI, Matthes KL, Rashbass J, Stiller C, Fitzpatrick D, Gavin A, Bannon F, Black RJ, Brewster DH, Huws DW, White C, Finan P, Allemani C, Bonaventure A, Carreira H, Coleman MP, Di Carlo V, Harewood R, Liu K, Matz M, Montel L, Nikšić M, Rachet B, Sanz N, Spika D, Stephens R, Peake M, Chalker E, Newman L, Baker D, Soeberg MJ, Aitken J, Scott C, Stokes BC, Venn A, Farrugia H, Giles GG, Threlfall T, Currow D, You H, Hendrix J, Lewis C.

Abstract

OBJECTIVE:

Ovarian cancers comprise several histologically distinct tumour groups with widely different prognosis. We aimed to describe the worldwide distribution of ovarian cancer histology and to understand what role this may play in international variation in survival.

METHODS:

The CONCORD programme is the largest population-based study of global trends in cancer survival. Data on 681,759 women diagnosed during 1995-2009 with cancer of the ovary, fallopian tube, peritoneum and retroperitonum in 51 countries were included. We categorised ovarian tumours into six histological groups, and explored the worldwide distribution of histology.

RESULTS:

During 2005-2009, type II epithelial tumours were the most common. The proportion was much higher in Oceania (73.1%), North America (73.0%) and Europe (72.6%) than in Central and South America (65.7%) and Asia (56.1%). By contrast, type I epithelial tumours were more common in Asia (32.5%), compared with only 19.4% in North America. From 1995 to 2009, the proportion of type II epithelial tumours increased from 68.6% to 71.1%, while the proportion of type I epithelial tumours fell from 23.8% to 21.2%. The proportions of germ cell tumours, sex cord-stromal tumours, other specific non-epithelial tumours and tumours of non-specific morphology all remained stable over time.

CONCLUSIONS:

The distribution of ovarian cancer histology varies widely worldwide. Type I epithelial, germ cell and sex cord-stromal tumours are generally associated with higher survival than type II tumours, so the proportion of these tumours may influence survival estimates for all ovarian cancers combined. The distribution of histological groups should be considered when comparing survival between countries and regions.

KEYWORDS:

Epidemiology; Histology; Morphology; Ovarain cancer; Worldwide

PMID:
27931752
PMCID:
PMC6195192
DOI:
10.1016/j.ygyno.2016.10.019
[Indexed for MEDLINE]
Free PMC Article

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