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J Asthma. 2017 Oct;54(8):856-865. doi: 10.1080/02770903.2016.1266496. Epub 2016 Dec 8.

Breastfeeding associated with higher lung function in African American youths with asthma.

Author information

1
a Department of Medicine , University of California San Francisco , San Francisco , CA , USA.
2
b Department of Pharmacy , University of California San Francisco , San Francisco , CA , USA.
3
c Department of Pediatrics , University of California San Francisco , San Francisco , CA , USA.
4
d Research Unit , Hospital Universitario NS de Candelaria , Santa Cruz de Tenerife , Spain.
5
e Department of Bioengineering and Therapeutic Sciences , University of California San Franscisco , San Francisco , CA , USA.
6
f Department of Pediatrics , Baylor College of Medicine , Houston , TX , USA.
7
g Department of Pulmonology , Texas Children's Hospital , Houston , TX , USA.
8
h Department of Primary Care , UCSF Benioff Children's Hospital , San Francisco , CA , USA.
9
i Department of Medicine , Northwestern University , Evanston , IL , USA.
10
j Department of Pediatric Pulmonology , Jacobi Medical Center , Bronx , NY , USA.
11
k Department of Pediatrics , Bay Area Pediatrics , Oakland , CA , USA.
12
l Department of Epidemiology , Johns Hopkins University Bloomberg School of Public Health , Baltimore , MD , USA.
13
m Department of Allergy and Immunology , Kaiser Permanente Vallejo Medical Center , San Francisco , CA , USA.
14
n Department of Pulmonary/Critica Care , VA Caribbean Healthcare System , San Juan , Puerto Rico.
15
o Department of Medicine , University of California Los Angeles David Geffen School of Medicine , Los Angeles , CA , USA.
16
p Department of Epidemiology and Biostatistics , University of California San Francisco , San Francisco , CA , USA.
17
q Department of Pediatric Pulmonology and Critical Care , Centro de Neumología Pediátrica , San Juan , Puerto Rico.
18
r Center for Health Policy and Health Services Research, Henry Ford Health System , Detroit , MI , USA.
19
s Department of Internal Medicine , Henry Ford Health System , Detroit , MI , USA.

Abstract

OBJECTIVE:

In the United States, Puerto Ricans and African Americans have lower prevalence of breastfeeding and worse clinical outcomes for asthma compared with other racial/ethnic groups. We hypothesize that the history of breastfeeding is associated with increased forced expiratory volume in 1 second (FEV1) % predicted and reduced asthma exacerbations in Latino and African American youths with asthma.

METHODS:

As part of the Genes-environments & Admixture in Latino Americans (GALA II) Study and the Study of African Americans, asthma, Genes & Environments (SAGE II), we conducted case-only analyses in children and adolescents aged 8-21 years with asthma from four different racial/ethnic groups: African Americans (n = 426), Mexican Americans (n = 424), mixed/other Latinos (n = 255), and Puerto Ricans (n = 629). We investigated the association between any breastfeeding in infancy and FEV1% predicted using multivariable linear regression; Poisson regression was used to determine the association between breastfeeding and asthma exacerbations.

RESULTS:

Prevalence of breastfeeding was lower in African Americans (59.4%) and Puerto Ricans (54.9%) compared to Mexican Americans (76.2%) and mixed/other Latinos (66.9%; p < 0.001). After adjusting for covariates, breastfeeding was associated with a 3.58% point increase in FEV1% predicted (p = 0.01) and a 21% reduction in asthma exacerbations (p = 0.03) in African Americans only.

CONCLUSION:

Breastfeeding was associated with higher FEV1% predicted in asthma and reduced number of asthma exacerbations in African American youths, calling attention to continued support for breastfeeding.

KEYWORDS:

Asthma; Hispanics; breastfeeding; exacerbations; genetic admixture; lung function; minority

PMID:
27929698
PMCID:
PMC6130885
DOI:
10.1080/02770903.2016.1266496
[Indexed for MEDLINE]
Free PMC Article

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