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Stress Health. 2016 Dec;32(5):503-513. doi: 10.1002/smi.2648. Epub 2015 Sep 29.

Stress, Inflammation and Pain: A Potential Role for Monocytes in Fibromyalgia-related Symptom Severity.

Author information

1
Department of Acute and Specialty Care, School of Nursing, University of Virginia, Charlottesville, VA, USA.
2
PhD Program, School of Nursing, University of Virginia, Charlottesville, VA, USA.
3
Division of Clinical Rheumatology, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA.
4
Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA, USA.

Abstract

The possibility that immunological changes might contribute to symptom severity in fibromyalgia (FM) prompted this proof-of-concept study to determine whether differences in monocyte subpopulations might be present in persons with FM compared with healthy controls. Relationships were assessed by comparing specific symptoms in those with FM (n = 20) and patterns of monocyte subpopulations with healthy age-matched and gender-matched controls (n = 20). Within the same time frame, all participants provided a blood sample and completed measures related to pain, fatigue, sleep disturbances, perceived stress, positive and negative affect and depressed mood (and the Fibromyalgia Impact Questionnaire for those with FM). Monocyte subpopulations were assessed using flow cytometry. No differences were observed in total percentages of circulating monocytes between the groups; however, pain was inversely correlated with percentages of circulating classical (r = -0.568, p = 0.011) and intermediate (r = -0.511, p = 0.025) monocytes in the FM group. Stress and pain were highly correlated (r = 0.608, p = 0.004) in the FM group. The emerging pattern of changes in the percentages of circulating monocyte subpopulations concomitant with higher ratings of perceived pain and the correlation between stress and pain found in the FM group warrant further investigation.

KEYWORDS:

biological mechanisms of disease processes; biological mechanisms of stress; stress

PMID:
27925450
DOI:
10.1002/smi.2648
[Indexed for MEDLINE]

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