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Parasite Immunol. 2017 May;39(5). doi: 10.1111/pim.12404. Epub 2017 Mar 22.

Helminths, hygiene hypothesis and type 2 diabetes.

Author information

1
Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands.
2
Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia.
3
Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
4
Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands.
5
Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands.

Abstract

Worldwide, there is little overlap between the prevalence of soil-transmitted helminths and type 2 diabetes (T2D). Helminth-induced type 2 immune responses and immune regulatory network might modulate the obesity-induced activation of inflammatory pathways that are associated with the development of insulin resistance, a strong predictor of the development of T2D. However, other factors such as helminth-associated changes in adiposity and gut microbiome might also contribute to improved metabolic outcomes. In this review, we summarize epidemiological evidence for the link between helminths and T2D and discuss the potential mechanisms, based on findings from experimental studies as well as the limited number of studies in humans.

KEYWORDS:

helminths; human; hygiene hypothesis; insulin resistance; metabolic disease; type 2 diabetes

PMID:
27925245
DOI:
10.1111/pim.12404
[Indexed for MEDLINE]
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