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Kidney Blood Press Res. 2016;41(6):956-965. doi: 10.1159/000452597. Epub 2016 Dec 8.

Association of MYH9 Polymorphisms with Hypertension in Patients with Chronic Kidney Disease in China.

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1
Division of Nephrology, The First Affiliated Clinical Hospital of Baotou Medical College, Baotou, China.

Abstract

BACKGROUND/AIMS:

This study explored the correlation between hypertension and non-muscle myosin heavy chain 9 (MYH9) gene polymorphisms in Chinese chronic kidney disease (CKD) patients.

METHODS:

This case-control study included 301 patients with CKD and 293 healthy controls. The E1 haplotype single nucleotide polymorphisms (SNPs) rs3752462 and rs4821480 were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. The association between MYH9 polymorphisms and high systolic blood pressure (SBP ≥ 140 mmHg) susceptibility in CKD patients was analysed.

RESULTS:

The cases and controls had similar genotype and allele distributions at rs3752462 and rs4821480. No GG genotype at rs4821480 was observed. Patients with SBP < 140 mmHg were more likely to have the CC genotype (17.1%) than patients with SBP ≥ 140 mmHg (4.3%) (P = 0.001). Creatinine clearance (OR = 0.99, 95% CI = 0.98-0.10, P = 0.01) was associated with SBP in patients with CKD. The risk of SBP ≥ 140 mmHg was 0.24-fold greater among patients with the CC genotype than among patients with the TT genotype (P = 0.002).

CONCLUSION:

The rs3752462 polymorphism of MYH9 is associated with SBP in patients with CKD. The T allele in the dominant model was associated with an elevated risk for high SBP.

PMID:
27924804
DOI:
10.1159/000452597
[Indexed for MEDLINE]
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