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J Infect Dis. 2016 Dec 15;214(12):1924-1928.

Differences in the Nasopharyngeal Microbiome During Acute Respiratory Tract Infection With Human Rhinovirus and Respiratory Syncytial Virus in Infancy.

Author information

1
Department of Pediatrics.
2
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
3
Infectious Disease Group.
4
Bioinformatics Group, J. Craig Venter Institute, Rockville, Maryland.
5
Department of Pathology, Microbiology, and Immunology.
6
Bioinformatics Group.
7
Genomic Medicine Group, J. Craig Venter Institute, La Jolla, California.
8
Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia.

Abstract

Respiratory viruses alter the nasopharyngeal microbiome and may be associated with a distinct microbial signature. To test this hypothesis, we compared the nasopharyngeal microbiome of 135 previously healthy infants with acute respiratory infection due to human rhinovirus (HRV; n = 52) or respiratory syncytial virus (RSV; n = 83). The nasopharyngeal microbiome was assessed by sequencing the V4 region of the 16S ribosomal RNA. Respiratory viruses were identified by quantitative reverse-transcription polymerase chain reaction. We found significant differences in the overall taxonomic composition and abundance of certain bacterial genera between infants infected with HRV and those infected with RSV. Our results suggest that respiratory tract viral infections are associated with different nasopharyngeal microbial profiles.

KEYWORDS:

children; human rhinovirus; microbiome; nasopharynx; respiratory syncytial virus

PMID:
27923952
PMCID:
PMC5142087
DOI:
10.1093/infdis/jiw456
[Indexed for MEDLINE]
Free PMC Article

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