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FEBS Lett. 1989 Sep 11;255(1):116-20.

Sequence similarity between dopamine beta-hydroxylase and peptide alpha-amidating enzyme: evidence for a conserved catalytic domain.

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1
Department of Medicinal Chemistry, Smith Kline & French Research Limited, Welwyn, England.

Abstract

A comparison of human dopamine beta-hydroxylase (EC 1.14.17.1) with bovine peptide C-terminal alpha-amidating enzyme (EC 1.14.17.3), revealed a 28% identity extending throughout a common catalytic domain of approximately 270 residues. The shared biochemical properties of these two enzymes from neurosecretory granules suggests that the sequence similarity reflects a genuine homology and provides a structural basis for a new family of copper type II, ascorbate-dependent monooxygenases.

PMID:
2792366
DOI:
10.1016/0014-5793(89)81072-5
[Indexed for MEDLINE]
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