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Clin Neurophysiol. 2017 Jan;128(1):204-214. doi: 10.1016/j.clinph.2016.11.004. Epub 2016 Nov 14.

Sleep EEG patterns in infants with congenital Zika virus syndrome.

Author information

1
UPE (University of Pernambuco), Recife, Brazil.
2
Associação de Assistência à Criança Deficiente (AACD), Recife, Brazil.
3
Department of Virology, Aggeu Magalhães Research Center, Fiocruz-PE, Brazil.
4
School of Medicine - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) and Brain Institute of Rio Grande do Sul (BraIns), Porto Alegre, Brazil. Electronic address: nunes@pucrs.br.

Abstract

OBJECTIVES:

To describe sleep EEG patterns of neonates, and infants with microcephaly due to congenital Zika virus (ZikV) syndrome.

METHODS:

A descriptive case series of EEGs performed in a cohort of neonates with microcephaly monitored from October 2015 to February 2016 at a University Hospital in Northeast Brazil. Infants were investigated following an established protocol that includes EEG, neuroimaging studies, PCR and specific antibodies for ZikV detection.

RESULTS:

EEGs (n=37) from 37 infants were reviewed. Age at investigation varied from 1 to 5months (mean=2.6). Diffuse low voltage (n=7), background asymmetry (n=6) and modified hypsarrhythmia with or without burst-suppression (n=11), were the main background abnormalities identified. Interictal EEG abnormalities were identified in 23 recordings (62%) and localized as focal frontal (n=8) or occipital (n=2) spikes/sharp, multifocal spikes/sharp waves (n=13). Electrographic seizures without clinical manifestation were identified in 4 recordings and characterized as focal pseudo rhythmic pattern. Further findings were focal high amplitude slow waves that were registered in the frontal (n=3) or occipital (n=1) regions.

CONCLUSIONS:

Different types of EEG abnormalities were encountered with a predominance of interictal epileptogenic activity and hypsarrhythmia.

SIGNIFICANCE:

Sleep EEGs in congenital Zika virus syndrome are consistently abnormal even in infants who have not yet developed epilepsy.

KEYWORDS:

EEG; Microcephaly; Newborns; Zika virus

PMID:
27923187
DOI:
10.1016/j.clinph.2016.11.004
[Indexed for MEDLINE]

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